IBJ EDITORIAL TEAM
EDITOR-IN-CHIEF
Antonio J Carcas Sansuán
Clinical Pharmacology / Hospital Universitario La Paz – Universidad Autónoma de Madrid
EXECUTIVE DEPUTY EDITORS
Alberto M. Borobia
Clinical Pharmacology / Hospital Universitario La Paz – Universidad Autónoma de Madrid
Jesús Frías Iniesta
Clinical Pharmacology / Hospital Universitario La Paz – Universidad Autónoma de Madrid
Miriam Estébanez Muñoz
Internal Medicine / Hospital Central de la Defensa “Gómez Ulla”
EDITORIAL BOARD
Adrián Llerena Ruíz
Clinical Pharmacology / Hospital Universitario Infanta Cristina – Universidad de Extremadura.
Antonio Fe Marqués
Medicina Interna – Enfermedades Infecciosas / Universidad Complutense de Madrid – Real Academia de Medicina de las Islas Baleares.
Antonio Rodríguez Artalejo
Internal Medicine – Infectious Diseases / Universidad Complutense de Madrid.
Carmen Ayuso
Genetics / Fundación Jiménez Díaz.
Concha Peiró
Clinical Pharmacology / Facultad de Medicina, Universidad Autónoma de Madrid.
Emilio Vargas Castrillón
Clinical Pharmacology / Hospital Clínico San Carlos – Instituto de Salud Carlos III – Universidad Complutense de Madrid.
Fernando Rodríguez Artalejo
Cardiovascular and nutritional epidemiology / Universidad Autónoma de Madrid.
Francisco Abad Santos
Clinical Pharmacology / Hospital Universitario de la Princesa.
Juan Antonio Vargas
Internal Medicine / Hospital Universitario Puerta de Hierro – Universidad Autónoma de Madrid.
Magi Farré Albaladejo
Clinical Pharmacology / Clínica del Hospital Universitari Germans Trias i Pujol – Universitat Autònoma de Barcelona.
Mar García Saiz
Clinical Pharmacology / Hospital Universitario de Canarias.
Maribel Lucena
Clinical Pharmacology / Hospital Universitario Virgen de la Victoria de Málaga – Universidad de Malaga.
Pedro Zapater Hernández
Clinical Pharmacology / Hospital General Universitario de Alicante – Universidad Miguel Hernández de Elche.
Rafael Dal-Ré
Public Health / Universidad Autónoma de Madrid.
Rodolfo Álvarez-Sala Walther
Pneumology / Hospital Universitario La Paz – Universidad Autónoma de Madrid.
EDITORS
Ana Aldea Perona
Clinical Pharmacology / Hospital Universitario de Canarias – Universidad de La Laguna.
Ana Peiró
Clinical Pharmacology / Hospital Universitario La Paz
Antonio Pérez
Pediatric Onco-hematology / Hospital Universitario La Paz.
David Martí Sánchez
Cardiology / Hospital Central de la Defensa “Gómez Ulla” – Universidad de Alcalá.
Dolores Ochoa
Clinical Pharmacology / Hospital Universitario La Princesa.
Emilio Cendejas
Microbiology and Infectious Diseases / Hospital Universitario La Paz.
Harvey I. Heredia Claure
Occupational Medicine / Universidad Mayor Real y Pontificia de San Francisco Xavier de Chuquisaca (UMRPSFXCH), Bolivia.
Hoi Yan Tong
Clinical Pharmacology / Hospital Universitario La Paz.
Jesús Mingorance
Microbiology / Hospital Universitario La Paz.
José Ignacio Bernardino
Internal Medicine / Hospital Universitario La Paz.
Judith Sanabria
Clinical Pharmacology / Hospital Universitario Virgen de la Victoria de Málaga – Universidad de Malaga.
Lucía Llanos Jiménez
Clinical Pharmacology – Family and Community Medicine / Fundación Jiménez Díaz – Hospital Severo Ochoa de Leganés.
María Dolores Martín Arranz
Gastroenterology / Hospital Universitario La Paz – Universidad Autónoma de Madrid.
Mario Fernández Ruiz
Infectious Diseases / Hospital Universitario 12 de Octubre – Instituto de Salud Carlos III – Universidad Complutense de Madrid.
Nuria Rodríguez Salas
Oncology / Hospital Universitario La Paz – Universidad Autónoma de Madrid.
Olga Laosa
Clinical Pharmacology – Family and Community Medicine / Hospital Universitario de Getafe.
STATISTICAL ADVISORS
José Carlos Martínez Ávila
Engineering PhD and Master in Biomedical Engineering. / Statistical Adviser.
COLLABORATORS
Naiara Salinas Barbosa
Press assistant and translator to Portuguese.
Nerea Cortázar Muñoz
Proofreader and layout designer.
ANTONIO J CARCAS SANSUÁN
MD, PhD
Specialist in Clinical Pharmacology. Associate Professor in the Department of Pharmacology at Universidad Autónoma of Madrid. Doctor of the Clinical Pharmacology Service at La Paz University Hospital. Scientific Coordinator of the Clinical Research Unit and Clinical Trials at La Paz University Hospital – IdiPAZ and Deputy chief of the Clinical Trials Unit of the Faculty of Medicine at Universidad Autónoma of Madrid
editor.ajc@ibjournals.com
C/ Arzobispo Morcillo 4, 28029, Madrid, España.
ALBERTO M. BOROBIA
MD, PhD
Specialist in Clinical Pharmacology. Clinical Professor Collaborator in the Department of Pharmacology at Universidad Autónoma of Madrid. Doctor of the Clinical Pharmacology Service at La Paz University Hospital. Coordinator of the Clinical Research Unit and Clinical Trials at La Paz University Hospital – IdiPAZ
JESÚS FRÍAS INIESTA
MD, PhD
Specialist in Clinical Pharmacology. Professor in the Department of Pharmacology at Universidad Autónoma of Madrid. Head of the Clinical Pharmacology Service at La Paz University Hospital. Director of the Clinical Research Unit and Clinical Trials at La Paz University Hospital – IdiPAZ and Clinical Trials Unit of the Faculty of Medicine at Universidad Autónoma of Madrid
MIRIAM ESTÉBANEZ MUÑOZ
MD, PhD
Specialist in Internal Medicine. Infectious Diseases Specialist. Internal Medicine Service Doctor – Central Hospital of Defense “Gómez Ulla”, Infectious Diseases Section, Madrid.
ADRIÁN LLERENA RUÍZ
MD, PhD and PhD in Surgery
pecialist in Clinical Pharmacology. CICAB Clinical Research Center. Health Area of Badajoz. University Hospital Infanta Cristina. Professor Linked to Extremadura Health Service, Department of Medicine, University of Extremadura Holder. Coordinator of the Central Clinical Research Unit and Clinical Trials Health Area of Badajoz, including the Platform for Clinical Research Units and Clinical Trials (SCReN – Spanish Clinical Research Network coordinator of the Latin American Network of pharmacogenetics, Member of the Section. Pharmacogenetics IUPHAR (International Union of Basic and Clinical Pharmacology, Board Member and former Vice President ESPT European Society of Personalized Therapeutics, Vice President Spanish Society of Pharmacogenetics and Pharmacogenomics. Delegate European Medicines Agency EMA Pharmacogenomics Working Party.
ANTONIO FE MARQUÉS
MD, PhD
Specialist in Internal Medicine – Infectious Diseases. Doctor of Medicine from the Universidad Complutense of Madrid. Corresponding Academician of the Royal Academy of Medicine of the Balearic Islands. Head of the Sub-inspection of Sanitary and Expert Support of the General Inspectorate of Defense Health.
ANTONIO RODRÍGUEZ ARTALEJO
MD,PhD
Professor of Pharmacology. Department of Toxicology and Pharmacology. Complutense University of Madrid. He directs a research group whose lines of work focus on the pharmacology of ion channels in the pathophysiology of neuropathic pain and neurodegeneration.
CONCHA PEIRÓ
MD,PhD
Specialist in Clinical Pharmacology. Professor of Pharmacology, in the Department of Pharmacology, Faculty of Medicine, Universidad Autónoma of Madrid. Researcher of the UAM group “FARMAVASM” (Vascular Pharmacology and Metabolism). Our main lines of research are focused on identifying pharmacological targets that may interfere with and delay the development of vasculopathy in the context of highly prevalent metabolic diseases, such as obesity or type 2 diabetes. Coordinator of the Ph.D. Program in Pharmacology and Physiology of UAM. Deputy Dean of the UAM Medical School between 2011-2015. Member of the board of directors of the Spanish society of pharmacology (since 2014).
EDUARDO LÓPEZ GRANADOS
MD,PhD
Specialist in Immunology. Doctor in Medicine by the Department of Biochemistry of the UAM. Coordinator of the Immunology Service, La Paz University Hospital. Director of the Research Group on lymphocyte pathophysiology in Immunodeficiencies, IdiPAZ. Member of the Steering Committee of the European Reference Network on Pediatric Transplantation, ERN-TRANSPLANTCHILD.
EMILIO VARGAS CASTRILLÓN
MD,PhD
Specialist in Clinical Pharmacology. Head of Pharmacology, Clinic San Carlos and Professor Linked to Clinical Pharmacology and Department of Pharmacology Head. Member of the Governing Board of the Spanish Agency for Medicines and Health Products. Chairman of the Supervisory Board of the Governing Council. second vice president of the National Committee of the Royal Spanish Pharmacopoeia. Research Associate Dean of the Faculty of Nursing, Physiotherapy, and Podiatry, Complutense University of Madrid. General coordinator of the Spanish Platform Support for Clinical Research and Clinical Trials, Carlos III Health Institute.
FERNANDO RODRÍGUEZ ARTALEJO
MD,PhD
Cardiovascular and nutritional epidemiology. Department of Preventive Medicine and Public Health. Universidad Autónoma de Madrid and CIBERESP. Professor of Preventive Medicine and Public Health. In recent years he has investigated the role of diet, physical activity and sedentary lifestyle on the onset of frailty syndrome and disability in older adults.
FRANCISCO ABAD SANTOS
MD,PhD
Specialist in Clinical Pharmacology. Head of the Clinical Pharmacology section, University Hospital de La Princesa. Head of the Central Clinical Research Unit and Clinical Trials in the University Hospital de la Princesa, including the Platform for Clinical Research Units and Clinical Trials (SCReN – Spanish Clinical Research Network).
JUAN ANTONIO VARGAS
MD,PhD and PhD in Surgery
Specialist in Internal Medicine. Professor and Dean of Medicine Department of Medicine, Faculty of Medicine, Autonomous University of Madrid. Deputy Head Section of Internal Medicine and the University Hospital Puerta de Hierro. Co-director of the Department of sponsorship UAM – LAIR Foundation on “Teaching and research in systemic immune-based diseases.”
MAGÍ FARRÉ ALBADALEJO
MD,PhD
Specialist in Clinical Pharmacology. Master in Pharmacoepidemiology and Master in Medical Ethics. Professor of Pharmacology, Department of Pharmacology, Therapeutics, and Toxicology at the Autonomous University of Barcelona. Head of Clinical Pharmacology, University Hospital Germans Trias i Pujol (HUGTP-GIBT) Badalona, Barcelona). Head of the Clinical Research Unit and Clinical Trials Platform SCReN-ISCIII of the center. His main area of research is the potential for abuse and human pharmacology of drugs and medicines and health consequences.
MAR GARCÍA SAIZ
MD,PhD
Specialist in Clinical Pharmacology. Doctor of the University of Cantabria and Master in Clinical Trials by the University of Seville. Head of the Clinical Pharmacology Service of the Hospital Universitario de Canarias. Chairman of the Research Ethics Committee of the Hospital Universitario de Canarias.
MARIBEL LUCENA
MD,PhD
Specialist in Clinical Pharmacology. Hepatotoxicity. Clinical trials. Pharmacoepidemiology. Risk factors. Causality. University of Malaga Clinical Pharmacology HUVV. Institute Malaga Biomedical Research. IBIMA. Professor in the Department of Pharmacology and Pediatrics and Director of the department of pharmacology and pediatrics of the faculty of medicine, University of Malaga. Scientific director of the Institute for Biomedical Research in Malaga, IBIMA. Head of Clinical Pharmacology, University Hospital Virgen de la Victoria Malaga and Coordinator of the platform for clinical research and clinical trials, IBIMA node, the Health Institute Carlos III. Member of the executive committee IUPHAR (International Union of Basic and Clinical Pharmacology) and the division of clinical pharmacology IUPHAR.
PEDRO ZAPATER HERNÁNDEZ
MD,PhD
Specialist in Clinical Pharmacology. Hospital General Universitario of Alicante. Professor of Pharmacology. Department of Pharmacology, Universidad Miguel Hernández of Elche.
RAFAEL DAL-RÉ
MD,PhD, MPH
Director, Clinical Research, BUC Program (Biociencias UAM + CSIC) of the Universidad Autonoma de Madrid. For more than 20 years, he has been director of the Medical Department in several multinational companies in the pharmaceutical industry. Also, it has been Manager of Clinical Research Program (Alzheimer) of Pasqual Maragall (Barcelona) Foundation between 2010 and 2012. Fellow of the Faculty of Pharmaceutical Medicine of the Royal Colleges of Physicians of the United Kingdom (1998-2010). Member of the National Commission of Pharmacovigilance (Mystery of Health) (1993-1996). The author of three books of ethics in clinical and epidemiological research.
RODOLFO ÁLVAREZ-SALA WALTHER
MD,PhD
Specialist in Pneumology. Head of Service of Pneumology. Hospital Universitario La Paz. Professor of Pulmonology, HULP, and La Universidad Autónoma de Madrid. He was the Medical Director of HULP. Areas of interest: Pneumology: interstitial lung diseases, COPD, sleep apnea-hypopnea syndrome, pneumonia, etc.
ANA ALDEA PERONA
MD,PhD
Specialist in Clinical Pharmacology. Coordinator of the Research Unit of the Hospital Universitario de Canarias. Associate professor in the Department of Pharmacology and Medical Physics of the University of La Laguna. Master in Clinical Trials. Master in Safety and Quality Assistive Patient. Higher Diploma in research methodology.
DAVID MARTÍ SÁNCHEZ
MD,PhD
Specialist in Cardiology. Master’s Degree in Cardiology and Acute Cardiac Care. Department of Cardiology, Central Hospital of Defense “Gómez Ulla”. Associate Professor, University of Alcalá. Member of the Directors Board of the Spanish Society of Cardiology.
HARVEY I.HEREDIA CLAURE
MD
pecialist in Occupational Medicine. Professor of the “CEPI” Center for Postgraduate Studies and Research of the Universidad Mayor Real and Pontificia de San Francisco Xavier de Chuquisaca (UMRPSFXCH), Bolivia. Labour Doctor at “Prevensalud Integral”. Expert in brief psychotherapy and clinical hypnosis.
JESÚS MINGORANCE
Biologist, PhD
Microbiology. Director of the Molecular Microbiology Group at the Microbiology Service of La Paz Hospital, IdiPAZ.
JOSÉ IGNACIO BERNARDINO DE LA SERNA
MD
Internal Medicine. Medical Assistant. HIV unit. Internal Medicine Service. University Hospital La Paz. IdiPAZ.
JUDITH SANABRIA
MD
Specialist in Clinical Pharmacology. She is part of the management area and monitoring of clinical trials in UICEC-IBIMA for the hospitals Virgen de la Victoria and Malaga Regional. She has participated as a collaborator in the managing of diverse national multi-centric projects from the SCReN platform, as well as in international projects related to drug safety (Project from the IMI SAFE-T Consortium and PRO EURO DILI- Grant Project from the European Association for the study of the liver – EASL). She takes part in the Spanish DILI Register. She is currently developing her doctoral thesis in the Biomedicine program of the University of Malaga, on drug-induced liver toxicity.
LUCÍA LLANOS JIMÉNEZ
MD,PhD
Specialist in Clinical Pharmacology and Family and Community Medicine. Adjunct Physician of the Clinical Research Unit of the Jiménez Díaz Foundation, where he carries out scientific and methodological advisory work, support for the development and promotion of independent clinical research. Vocal of the CEIC of Severo Ochoa Hospital of Leganés. Technical Secretary of the CEIC and FJD.
MARÍA DOLORES MARTÍN ARRANZ
MD,PhD
Specialist in Gastroenterology. Head of the Digestive System Section at La Paz University Hospital. Associate Professor of Medicine at the Autonomous University of Madrid. In charge of the creation and development of the Inflammatory Bowel Disease Unit in HULP. In charged of the Hospital´s Endoscopy Unit. She has participated in multiple clinical trials and research studies with multiple national and international publications.
MARIO FERNÁNDEZ RUIZ
MD, PhD
Specialist in Internal Medicine. Master of Infection in the Immunodepressed Patient “at the Complutense University. Trained in the Infectious Diseases Service of the Clinic Hospital of Barcelona and in the Multi-Organ Transplant Program at the Toronto General Hospital. The beneficiary of a contract “Juan Rodés” of the Carlos III Health Institute. His main line of research focuses on infection in the solid organ transplant recipient, in the development and validation of immunological monitoring strategies in this population, and invasive fungal infection. He is the author or co-author of more than 130 publications in national and international journals and received, among others, the “Young Internist of the Year 2014” Award for his research activity.
NURIA RODRÍGUEZ SALAS
MD, PhD
Specialist in Medical Oncology. Responsible for the heredofamilial cancer unit in the Department of Medical Oncology at La Paz University Hospital. Associate professor of health sciences at the Universidad Autónoma de Madrid.
OLGA LAOSA
MD
Specialist in Family and Community Medicine and Clinical Pharmacology. Currently, she works as Clinical Pharmacologist in the Foundation for Biomedical Research of the University Hospital of Getafe in Madrid, Spain. She has over 13 years of experience in clinical trials, 6 of which focused on the elderly population. She is now participating as a co-researcher on three international research projects funded by the European Commission: MID FRIL, SPRINTT and ACANTO. Two of these are clinical trials in elderly subjects in Europe. He is currently responsible for the Clinical Trials Unit in the elderly of the University Hospital of Getafe (CICA) and also works as a clinical pharmacologist on the Ethics Committee of the University Hospital of Getafe.